Introduction
No conclusive, prospective randomized trials Gat clearly offer definitive guidelines for
Many questions remain
When is lymph node sampling helpful?
What is the value of postoperative radiation? endometrial carcinoma, uterine cancer, cancer of the uterus, endometrial cancer, endometreal cancer
What is the value of adjunctlye chemotherapy? endometrial carcinoma, uterine cancer, cancer of the uterus, endometrial cancer
What is the role of hormone therapy?
Which chemotherapeutic agents are active?
Epidemiology And Risk
Incidence: 2002 American Cancer Society projections endometrial carcinoma, uterine cancer, cancer of the uterus, endometrial cancer
Most common gynecologic cancer (after breast)
Third: colorectal (66,000) endometrial carcinoma, uterine cancer, cancer of the uterus, endometrial cancer, endometreal cancer
Fourth: endometrial 04,000) endometrial carcinoma, uterine cancer, cancer of the uterus, endometrial cancer, endometreal cancer
B. Distribution by stage: International Federation of Gynecology and endometrial carcinoma, uterine cancer, cancer of the uterus, endometrial cancer Obstetrics
Stage I: 75%
Stage II: 15%
Stage III: 7%
Stage IV: 3%
Estimate of risk
Geographic: the white population in the United States has the endometrial carcinoma, uterine cancer, cancer of the uterus, endometrial cancer highest age-adjusted incidence in the world
Race: United States
White peak: 87% in 100,000 at 65-70 years endometrial carcinoma, uterine cancer, cancer of the uterus, endometrial cancer
Black peak: 78 % in 100,000 at 75-80 years
3. Age
Postmenopausal: 75-80%
Mean age at diagnosis: 61 years
<5 % below age 40
4. Obesity
From 20-50 lbs overweight: 3X
Over 50 lbs overweight: 9X
Diabetes: up to 3X increased risk
Hypertension
Parity
One-third nulliparous
Risk decreases with