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Henoch-Schönlein Purpura

Henoch-Schönlein purpura, also referred to as anaphylactoid purpura is a systemic vasculitis syndrome characterized by palpable purpura (usually distributed over the buttocks and lower extremities), arthralgias, gastrointestinal signs and symptoms, and glomerulonephritis. It is a

Incidence And Prevalence

Henoch-Schönlein purpura is usually seen in children, age from 4 to 7 years; however, the disease may also be seen in infants and adults. It is not a rare disease, accounting for

Pathophysiology And Pathogenesis

The presumptive pathogenic mechanism for Henoch-Schönlein purpura is immune-complex deposition. A number of inciting antigens have been suggested including upper respiratory tract infections, various drugs, foods, insect bites,

Clinical And Laboratory Manifestations

In pediatric patients, presenting symptoms related to the skin, gut, and joints are present in 50 percent of cases. In adults, presenting symptoms related to the skin are seen in over 70 percent of patients, while initial complaints related to the gut or the joints are noted in fewer than 20 percent of cases. The typical palpable purpura is seen in


The prognosis of Henoch-Schönlein purpura is excellent. Most patients recover completely, and some do not require therapy. Treatment is similar for adults and children. When glucocorticoid therapy is required, prednisone in, henoc, shonline