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Physicians' Drug Reference

Medical Library. Full Text Journals Medical Books Online. Physicians Drug Reference

Color Atlas of Skin Diseases

Cilostazol Pletal


Denileukin diftitox (interleukin-2 fusion protein, DAB389IL-2)

ANCESTIM (Stemgen)

BALSALAZIDE (Colazide by Salix Pharmaceuticals)


ETANERCEPT (Enbrel by Immunex) A TNFa inhibitor

ZONISAMIDE (Zonegran by Athena Neurosciences)

RIZATRIPTAN (MK-462) (Maxalt by Merck)

EPTIFIBATIDE (Integrilin by COR Therapeutics)

THALIDOMIDE (Thalomid by Celegene)

TOLTERODINE TARTRATE (Detrusitol by Pharmacia and Upjohn)

ARGATROBAN (Novastan by SmithKline Beecham/Texas Biotechnology Corporation)

SURAMIN (Metaret by Parke-Davis) an antineoplastic.

OPRELVEKIN (Neumega by Genetics Institute and American Home Products)

ZOLMITRIPTAN (Zomig by Zeneca) A serotonin-1B/1D receptor agonist.

141W94 protease inhibitor Phase II HIV Glaxo Wellcome

1592489 antiviral Phase II HIV Glaxo Wellcome

Abacavir (1592489) protease inhibitor NDA filed HIV Glaxo Wellcome

Acemannan (Carrisyn) antiviral, immunomodulator Phase I AIDS Carrington Laboratories

Acetylcysteine (Fluimucil) immunomodulator Phase I HIV, AIDS Zambon

ACT (activated cellular therapy) other Phase I AIDS Neoprobe

AD-439 antiviral Phase II HIV, AIDS Tanox Biosystems

AD-439 and AD-519 Combination antiviral Phase II HIV, AIDS Tanox Biosystems

AD-519 antiviral Phase II HIV, AIDS Tanox Biosystems

Adefovir dipivoxil antiretroviral Phase II/III; HIV Gilead Science

AIDS vaccine (eg, gp 120, rgp 160, rgp 160 MN, rp 24, VaxSyn HIV-1) antiviral Phase I to III AIDS, HIV prophylaxis and treatment MicroGeneSys/Genentech/Immuno/

Connaught/Virogenetics/United Biomedical

AL-721 antiviral Phase I/II AIDS, HIV Matrix Laboratories

Aldesleukin 1 (interleukin-2>; IL 2; Proleukin) cytokine Phase II with zidovudine for HIV Cetus Oncology

Alferon LDO interferon alfa-n3 antiviral Phase I/II ARC/AIDS Interferon

Alferon N Injection interferon alfa-n3 antiviral Phase III HIV Interferon Sciences

ALVAC-HIV 1 gp160 MN vaccine Phase I HIV Pasteur Merieux Connaught

Ampligen immunomodulator Phase II/III HIV HEM Pharmaceutical

Alvircept sudotox (sCD4-PE40) antiviral Phase II AIDS Upjohn

AR-121 (Nystatin-LF I.V.) antiviral Phase I/II HIV Argus

AR177 integrase inhibitor Phase I; HIV Aronex

AS-101 immunomodulator Phase I/II AIDS Wyeth-Ayerst

Atevirdine mesylate antiviral Phase I HIV, AIDS Pharmacia and Upjohn

Azidouridine (AzdU) antiviral Phase I HIV-positive symptomatic, AIDS Berlex

Aztec (Zidovudine) antiviral Phase III HIV, AIDS Verex

AZT-P-ddI (Scriptene) antiviral Phase I AIDS Baker Norton

BCX-34 Phase III HIV BioCryst Pharmaceuticals

BMS-234475 protease inhibitor Phase III HIV Bristol-Myers Squibb

Calanolide A non-nucleoside inhibitor Phase I HIV MediChem

CD4, soluble human, recombinant antiviral Phase II AIDS Biogen

CD4-IgG antiviral Phase I Maternal/fetal HIV transfer Genentech

Cidofivir1 (Visitide) antiviral Phase I/II, AIDS Gilead

CI-1012 antiviral Phase I HIV Warner-Lambert

CI-1020 antiviral IND, HIV Warner Lambert

Coenzyme Q10 immunodulator Phase I HIV Ryan Pharmaceuticals

CTL (adoptive immuno-therapy) gene therapy Phase I HIV Targeted Genetics

Curdlan sulfate antiviral Phase II HIV AJI Pharmaceuticals

CY2301 vaccine IND HIV Cytel

Cytolin nontoxid AIDS monoclonal antibody Phase I/II AIDS CytoDyn

DAB389IL-2 fusion toxin cytokine Phase I/II HIV Seragen

Delavirdine mesylate antiviral Phase III HIV, AIDS Pharmacia and Upjohn

Deoxynojirimycin, n-butyl (DNJ) antiviral Phase II ARC, AIDS Searle

Dextran sulfate (Uendex) antiviral Phase II AIDS, HIV-positive asymptomatic Ueno Fine Chemicals Industry Ltd.

Diethyldithiocarbamate (Imuthiol) immunomodulator Phase II/III AIDS, HIV, pediatric HIV Connaught

DMP-266 non-nucleoside reverse transcriptase inhibitor antiviral Phase II HIV DuPont Merck

DMP-450 (second generation protease inhibitor) antiviral Phase I/II HIV AVID/DuPont Merck

Efavirenz (DMP 266) non-nucleoside reverse transcriptase inhibitor NDA filed HIV DuPont Merck

Fiacitabine (FIAC) antiviral Phase I/II HIV, AIDS Oclassen

Fialuridine (FIAU) antiviral Phase II HIV Oclassen

Filgrastim 1 (granulocyte colony-stimulating factor; G- CSF; Neupogen) cytokine Phase III AIDS Amgen

FK-565 immunomodulator Phase I HIV Fujisawa

Fluorothymidine (FLT) antiviral Phase II HIV, AIDS Lederle


(Cytovene) antiviral Phase I/II, HIV prophylaxis Roche

GEM 91 antiviral Phase II IV Hybridon

Genevax-HIV-Px vaccine Phase I HIV Apollon

gp 120 vaccine (Remune) vaccine Phase II, HIV prophylaxis Genevax

gp 160 vaccine vaccine Investigational; HIV prophylaxis Micro Genesys

HBY097 non-nucleoside reverse transcriptase inhibitor antiviral Phase II HIV Hoechst Marion Roussel

Hematopoietic stem cell gene therapy gene therapy Phase I/II HIV SyStemix

HGP-30 vaccine Phase I HIV Viral Technologics

HIV immune globulin (HIVIG) immunomodulator Phase III Prevention of maternal/fetal HIV transfer North American Biologicals

HIV immuno-therapeutic antiviral Phase I HIV (symptomatic) Viagene

HIV immuno-therapeutic vaccine antiviral Phase II/III HIV asymptomatic Immunization Products Ltd. (joint venture of RPR and Immune Response Corp.)

HIV-IT (V) gene therapy Phase II IV Chiron

HIV Therapeutic other Phase I/II HIV/AIDS United Biomedical

HIV vaccine (gp120) antiviral Phase I AIDS Chiron/Ciba-Geigy

HIV Vaccine (Apollon) vaccine HIV Genevax

HIV Vaccine (Genevax) vaccine Phase I/II, HIV prophylaxis Apollon, Wyeth-Ayerst

HIV-1 peptide vaccine vaccine Phase I HIV National Cancer Institute

Hypericin (VIMRxyn

) antiviral Phase I AIDS, HIV VIMRx Pharm

Immune globulin IV 1 (IGIV; eg, Gamimune-N) immunomodulator Phase II/III Pediatric HIV; with zidovudine for AIDS Miles


immunomodulator Phase III HIV Imreg

Interferon alfa (Wellferon) cytokine Phase III with zalcitabine and zidovudine for HIV disease, non-AIDS Glaxo Wellcome

Interferon, alfa-2b 1 (Intron A) cytokine Phase I/II with zidovudine for AIDS Schering-Plough

Interferon, alfa-n3 1 (Alferon N

; Alferon LDO

[low-dose oral]) cytokine Phase I/II ARC, AIDS, asymptomatic AIDS Interferon Sciences

Interferon, beta (Betaseron) cytokine Phase II/III AIDS Berlex

Interleukin-1receptor, soluble antiviral Phase I HIV Immunex

Interleukin-2 PEG cytokine Phase II with zidovudine for AIDS Chiron

Interleukin-3, recombinant human cytokine Phase I HIV with cytopenia Sandoz

Iscador antiviral Phase I HIV, AIDS Hiscia

Lentinan (Lentinan-

jinomoto) immunomodulator Phase II/III with didanosine for AIDS HIV-positive (symptomatic/asymptomatic), AIDS, pediatric AIDS Lenti-Chemico Pharmaceuticals

MDX-240 Phase II AIDS Medarex

Molgramostim (GM-CSF; (Leucomax) cytokine Phase II/III With zidovudine for AIDS Sandoz/Genetics Institute/Schering-Plough

Monoclonal antibody (MSL-109; MAb) antiviral Phase I AIDS Sandoz

Nelfinavir (Viracept) antiviral Phase III Agouron


antiviral Phase I HIV inhibitor Novaferon Labs

Panavir (probucol) antiviral Phase II HIV, AIDS Vyrex

Panretin Oral (ALRT 1057) immunomodulator Phase I/II HIV Ligand Pharma Allergan-Ligand

Pentafuside Phase I/II HIV MiniMed

PMEA (GS 393) antiviral Phase I/II HIV Gilead Sciences

PMPA other Phase I/II HIV Gilead Sciences

PNU-140690 (protease inhibitor) antiviral Phase I HIV, AIDS Pharmacia & Upjohn

Proleukin aldesleukin, interleukin-2 (IL-2) immunomodulator Phase II HIV Chiron

RBC-CD4 antiviral Phase I/II HIV Sheffield Medical Tech.

Remune HIV immunotherapeutic vaccine Phase III IV Immune Response

rhIL-12 (recombinant human interleukin-12) immunomodulator Phase I HIV Genetics Institute

Ribavirin 1 (Virazole) antiviral Phase II/III Asymptomatic HIV posi- tive; IND denied Viratek/ICN

Roquinimex (Linomide) immunomodulator Phase II HIV Kabi Pharmacia

Sargramostim 1 (granulocyte macrophage colony stimulating factor; GM- CSF; Leukine) cytokine Phase II HIV Immunex

SPC3 other Phase I/II HIV Columbia Laboratories

Stimulon QS-21 vaccine Phase I/II Aquila Biopharmaceuticals

T4, soluble human, recombinant antiviral Phase I/II HIV Biogen

TAT antagonist antiviral Phase I/II IV Hoffman LaRoche

TBC-3B vaccine Phase I AIDS Therion Biologics

T-cell gene therapy gene therapy Phase III HIV Cell Genesys

Thalidomide cytokine inhibitor Approvable AIDS Celegene

Thymic humoral factor immunomodulator Phase I HIV Adria

Thymopentin (Timunox) immunomodulator Phase III Asymptomatic HIV Immunobiology Research Institute

Thymostimuline (TP-1) immunomodulator Phase III AIDS Serono Laboratories

Timunox thymopentin immunomodulator Phase III HIV Immunobiology Research Institute

Tirilazed Mesylate protease inhhibitor Phase I/II HIV Glaxo Wellcome

Trichosanthin (GLQ223

; Compound Q) antiviral Phase II ARC, AIDS Genelabs Technologies

Tucaresol (immunopotentiator) antiviral Phase I/II HIV Glaxo Wellcome

Tumor necrosis factor (TNF) antiviral Phase I HIV Immunex


cytokine Phase I AIDS Veldona USA

Videx (didanosine with Retrovir

zidovidine [AZT]) antiviral application submitted HIV Bristol-Myers Squibb

Videx (didanosine [ddI] with Zerit

stavudine [d4T]) antiviral application submitted HIV Bristol-Myers Squibb

VIMRxyn hypericin antiviral Phase I HIV, AIDS VIMRx Pharma

VX478 antiviral Phase II AIDS, HIV Vertex Pharmaceuticals

Zintevir (AR177) antiviral Phase I/II HIV Aronex Pharmaceuticals

1 Approved for other indications; refer to individual monographs.


Provigil (Cephalon) - Rx

Tablets: 100 mg modafinil. (Provigil 100 mg). In 100s.

200 mg modafinil. (Provigil 200 mg). Scored. In 100s. White. Lactose, talc.

Indications: Improve wakefulness with excessive daytime sleepiness in narcoleptic patients.

LYMErix Vaccine (SmithKline Beecham) - Rx

Injection: 30 mcg/0.5 ml recombinant lipoprotein OspA adsorbed onto 0.5 mg aluminum hydroxide adjuvant. In single-dose vials and prefilled syringes.

Indications: Active immunization against Lyme disease in patients 15 to 70 years of age.