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Intensive Insulin Therapy in Type 2 Diabetes and Development or Progression of Microvascular Complications type 2 diabetes, diabetes, insulin
Development or Progression of Complication (%)
Retinopathy:PrimaryPrevention |
Retinopathy:Secondary Intervention type 2 diabetes, diabetes, insulin |
Nephropathy:Primary Prevention type 2 diabetes mellitus, diabetes, insulin |
Nephropathy:Secondary Intervention Type 2 Diabetes Mellitus Insulin type 2 diabetes mellitus, diabetes, insulin |
|
IntensiveTherapy (Mean HbAlc 7.1%) Type 2 Diabetes Mellitus Insulin Type 2 Diabetes Mellitus Insulin |
8 |
19 |
8 |
12 |
ConventionalTherapy (Mean type 2 diabetes mellitus, diabetes, insulin HbAlc 9.4%) |
32 |
44 |
28 |
32 |
Type 2 Diabetes Mellitus
· Pathophysiology
Strong genetic component: 90% concordance in identical twins
Multiple genes presumed
Combined defects in insulin secretion and insulin action: insulin sensitivity predicts disease
Obesity major risk factor
·Age of Onset/Predictors
Majority > age 40
Gestational diabetes, obesity are predictors diabetis