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Rheumatic and Vasculitic Disorders


Lupus is an episodic, multi-system autoimmune disease.

Widespread inflammation of Henoch-Schonlein purpura, Kawasaki disease, polyarteritis nodosa blood vessels and connective tissue is characteristic

Autoantibody production

Epidemiology of Lupus

Rheumatic and Vasculitic Disorders Rheumatic and Vasculitic Disorders Lupus Lupus

Prevalence in adults is 30/100,000 Henoch-Schonlein purpura, polyarteritis nodosa, Henoch Schonlein purpura, Henoc, Schonlen

Prevalence in children is unknown. There are 10,000 cases/year in the U.S.

Age of onset is 10-20

Female to male ratio = 5:1 in childhood (2:1 under age 10)

Prevalence of SLE in African and Asian young women approaches 1/2000

Higher prevalence rates in Hispanics, Native Americans

Clinical Features of Lupus

The lupus triad





Cutaneous findings

Musculoskeletal symptoms

Renal abnormalities

Cardiopulmonary rheumatic, vasculitis, vasculitic disorders, lupus manifestations