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Amantadine Acyclovir Zidovudine
Rimantadine Famciclovir Didanosine
Ribavirin Valacyclovir Zalcitabine
Ganciclovir Stavudine
Foscarnet Lamivudine
Cidofovir Nevirapine
Vidarabine Saquinavir
Trifluridine Indinavir
Ritonavir
Nelfinavir
Delavirdine
· adamantyl case structure interferes with transmembrane proton (H+) transport initiated by influenza A membrane protein M2
· blockage of H+ channel reduces intracellular acidification necessary for fusion of influenza A to host cell endosomal membranes and release of rind RNA
· influenza B lacks M2 protein
· Prophylaxis of influenza A
· Treatment of influenza A
- efficacy greatest if given within 48 hours of onset of symptoms
- rimantadine