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Atopic DermatitisAtopic dermatitis has an incidence of 7/1,000 and a prevalence of 3-5% of children. 95% of affected children will have symptoms by age 5. The inheritance pattern is multifactorial. Pathogenesis is related to Triggering factors Foods, environmental allergens, and bacteria. Individual with genetic predisposition Inflammatory mediators: Histamine, prostaglandins, neuropeptides Contact Dermatitis Inflammation Pruritus Acute dermatitis Chronic dermatitis External factors including foods, bacteria, and environmental allergens trigger the release of cutaneous inflammatory factors, resulting in pruritus and inflammation of the skin of susceptible individuals. Rash, rashes Secondary manipulation of the skin [i.e. rubbing and excoriation) produces many of the symptoms of acute and chronic dermatitis. Dermatitic changes in the skin. Diagnostic Criteria for Atopic Dermatitis Major criteria (all required for diagnosis) Common findings (at least two) Associated findings (at least four) Pruritus Typical morphology and distribution of rash Personal or family history of atopy Immediate skin test reactivity White dermographism Anterior subcapsular cataracts Ichthyosis, xerosis, hyperlinear palms Pityriasis alba Keratosis pilaris Facial pallor, infraorbital darkening Dennie-Morgan folds Keratoconus Hand dermatitis Repeated cutaneous infections Complications of Atopic Dermatitis rash, rashes Secondary bacterial infection Viral infections (herpes simplex, molluscum) Chronic fungal infection Differential Diagnosis Seborrheic dermatitis Irritant dermatitis Papular acrodermatitis Psoriasis Fungal infection Scabies Treatment of Atopic Dermatitis
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