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Treatment of Type I Diabetes Mellitus and its Complications

Pathophysiology of Type I Diabetes

Diabetes mellitus comprises a diverse group of heterogeneous disorders which have hyperglycemia as a common manifestation. Increasing evidence is accruing that even mild degrees of hyperglycemia are associated with long-term complications and an increased risk of cardiovascular disease.


Types of Diabetes



Age of onset/predictors

Type I (IDDM)

Autoimmune beta cell destruction

Younger with 40% < 20

Can occur at any age, +FH

 Type II (NIDDM)

 Multiple genes presumed

(none identified to date)

Obesity major risk factor

Older; majority > 40; Gestational; obesity

MODY (maturity onset)

Glucokinase gene mutations

 in < 20%