Gestational trophoblastic disease (GTD): "benign" trophoblastic disease
Transitional mole
Incomplete mole/partial mole
Hydatidiform mole
Gestational trophoblastic neoplasia (GTN'): gestational trophoblastic neoplasia.
Hydatidiform mole
Invasive mole
Placental site tumor (Trophoblastic pseudotumor)
Choriocarcinoma
Blighted ovum: transitional
Embryo or membranes present
Minimal trophoblastic proliferation
No cistern formation
Villi only slightly enlarged
Genetically abnormal
Placental site trophoblastic tumor (trophoblastic pseudotumor)
An indolent neoplasm composed of the intermediate trophoblast
Usually confined to the uterus
Chorionic villi are absent
Failure of development of fetal circulation with resultant hydropic swelling of villi
Overgrowth of the villous trophoblast with secondary hydropic swelling
There is an increased risk of complete hydatidiform mole at both ends of the reproductive age spectrum, ie, teenagers and women over 40 years of age
Malignant sequelae after complete hydatidiform mole occur more frequently in women over 40 years of age
Maternal age appears to have no effect on the risk of complete hydafidiform mole or partial mole
4. Paternal age does not appear to have an effect on the risk of complete hydatidiform mole or partial mole
C. Geographic incidence of GTN