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New Treatments for Hypertension
Hypertension is the chronic disease accounting for the largest number of physician office visits.
25-30% of the U. S. adult population
More prevalent in men than women.
African-Americans:
Higher overall prevalence of HTN.
Higher HTN associated morbidity.
More likely to develop HTN at younger age.
Higher proportion of hypertensives with Stage III-IV HTN (12% vs 6% in white hypertensives).
Morbidity of Hypertension
End stage renal disease
Coronary artery disease/myocardial infarction
Stroke
Relative risk of stroke and CAD at various diastolic bp levels in untreated patients:
|
Usual Diastolic
Blood Pressure |
Relative Risk
Of Cad |
Relative Risk of Stroke | ||
| Lancet * | MRFIT** | Lancet | MRFIT | |
| 76 | 0.5 | 0.67 | 0.3 | 0.51 |
| 84 | 0.7 | 0.80 | 0.5 | 0.74 |
| 91 | 1.0 | 1.00 | 1.0 | 1.00 |
| 98 | 1.5 | 1.16 | 1.8 | 1.46 |
| 99-105 | 2.0 | 1.68 | 3.5 | 2.25 |