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Physicians' Drug Reference
Medical Library. Full Text Journals Medical Books Online. Physicians Drug Reference
Color Atlas of Skin Diseases
Cilostazol Pletal
DENILEUKIN DIFTITOX Ontak
Denileukin diftitox (interleukin-2 fusion protein, DAB389IL-2)
ANCESTIM (Stemgen)
BALSALAZIDE (Colazide by Salix Pharmaceuticals)
BOSENTAN
ETANERCEPT (Enbrel by Immunex) — A TNFa inhibitor
ZONISAMIDE (Zonegran by Athena Neurosciences)
RIZATRIPTAN (MK-462) (Maxalt by Merck)
EPTIFIBATIDE (Integrilin by COR Therapeutics)
THALIDOMIDE (Thalomid by Celegene)
TOLTERODINE TARTRATE (Detrusitol by Pharmacia and Upjohn)
ARGATROBAN (Novastan by SmithKline Beecham/Texas Biotechnology Corporation)
SURAMIN (Metaret by Parke-Davis) — an antineoplastic.
OPRELVEKIN (Neumega by Genetics Institute and American Home Products)
ZOLMITRIPTAN (Zomig by Zeneca) — A serotonin-1B/1D receptor agonist.
141W94 protease inhibitor Phase II HIV Glaxo Wellcome
1592489 antiviral Phase II HIV Glaxo Wellcome
Abacavir (1592489) protease inhibitor NDA filed HIV Glaxo Wellcome
Acemannan (Carrisyn) antiviral, immunomodulator Phase I AIDS Carrington Laboratories
Acetylcysteine (Fluimucil) immunomodulator Phase I HIV, AIDS Zambon
ACT (activated cellular therapy) other Phase I AIDS Neoprobe
AD-439 antiviral Phase II HIV, AIDS Tanox Biosystems
AD-439 and AD-519 Combination antiviral Phase II HIV, AIDS Tanox Biosystems
AD-519 antiviral Phase II HIV, AIDS Tanox Biosystems
Adefovir dipivoxil antiretroviral Phase II/III; HIV Gilead Science
AIDS vaccine (eg, gp 120, rgp 160, rgp 160 MN, rp 24, VaxSyn HIV-1) antiviral Phase I to III AIDS, HIV prophylaxis and treatment MicroGeneSys/Genentech/Immuno/
Connaught/Virogenetics/United Biomedical
AL-721 antiviral Phase I/II AIDS, HIV Matrix Laboratories
Aldesleukin 1 (interleukin-2>; IL 2; Proleukin) cytokine Phase II with zidovudine for HIV Cetus Oncology
Alferon LDO interferon alfa-n3 antiviral Phase I/II ARC/AIDS Interferon
Alferon N Injection interferon alfa-n3 antiviral Phase III HIV Interferon Sciences
ALVAC-HIV 1 gp160 MN vaccine Phase I HIV Pasteur Merieux Connaught
Ampligen immunomodulator Phase II/III HIV HEM Pharmaceutical
Alvircept sudotox (sCD4-PE40) antiviral Phase II AIDS Upjohn
AR-121 (Nystatin-LF I.V.) antiviral Phase I/II HIV Argus
AR177 integrase inhibitor Phase I; HIV Aronex
AS-101 immunomodulator Phase I/II AIDS Wyeth-Ayerst
Atevirdine mesylate antiviral Phase I HIV, AIDS Pharmacia and Upjohn
Azidouridine (AzdU) antiviral Phase I HIV-positive symptomatic, AIDS Berlex
Aztec (Zidovudine) antiviral Phase III HIV, AIDS Verex
AZT-P-ddI (Scriptene) antiviral Phase I AIDS Baker Norton
BCX-34 Phase III HIV BioCryst Pharmaceuticals
BMS-234475 protease inhibitor Phase III HIV Bristol-Myers Squibb
Calanolide A non-nucleoside inhibitor Phase I HIV MediChem
CD4, soluble human, recombinant antiviral Phase II AIDS Biogen
CD4-IgG antiviral Phase I Maternal/fetal HIV transfer Genentech
Cidofivir1 (Visitide) antiviral Phase I/II, AIDS Gilead
CI-1012 antiviral Phase I HIV Warner-Lambert
CI-1020 antiviral IND, HIV Warner Lambert
Coenzyme Q10 immunodulator Phase I HIV Ryan Pharmaceuticals
CTL (adoptive immuno-therapy) gene therapy Phase I HIV Targeted Genetics
Curdlan sulfate antiviral Phase II HIV AJI Pharmaceuticals
CY2301 vaccine IND HIV Cytel
Cytolin nontoxid AIDS monoclonal antibody Phase I/II AIDS CytoDyn
DAB389IL-2 fusion toxin cytokine Phase I/II HIV Seragen
Delavirdine mesylate antiviral Phase III HIV, AIDS Pharmacia and Upjohn
Deoxynojirimycin, n-butyl (DNJ) antiviral Phase II ARC, AIDS Searle
Dextran sulfate (Uendex) antiviral Phase II AIDS, HIV-positive asymptomatic Ueno Fine Chemicals Industry Ltd.
Diethyldithiocarbamate (Imuthiol) immunomodulator Phase II/III AIDS, HIV, pediatric HIV Connaught
DMP-266 non-nucleoside reverse transcriptase inhibitor antiviral Phase II HIV DuPont Merck
DMP-450 (second generation protease inhibitor) antiviral Phase I/II HIV AVID/DuPont Merck
Efavirenz (DMP 266) non-nucleoside reverse transcriptase inhibitor NDA filed HIV DuPont Merck
Fiacitabine (FIAC) antiviral Phase I/II HIV, AIDS Oclassen
Fialuridine (FIAU) antiviral Phase II HIV Oclassen
Filgrastim 1 (granulocyte colony-stimulating factor; G- CSF; Neupogen) cytokine Phase III AIDS Amgen
FK-565 immunomodulator Phase I HIV Fujisawa
Fluorothymidine (FLT) antiviral Phase II HIV, AIDS Lederle
Ganciclovir1
(Cytovene) antiviral Phase I/II, HIV prophylaxis Roche
GEM 91 antiviral Phase II IV Hybridon
Genevax-HIV-Px vaccine Phase I HIV Apollon
gp 120 vaccine (Remune) vaccine Phase II, HIV prophylaxis Genevax
gp 160 vaccine vaccine Investigational; HIV prophylaxis Micro Genesys
HBY097 non-nucleoside reverse transcriptase inhibitor antiviral Phase II HIV Hoechst Marion Roussel
Hematopoietic stem cell gene therapy gene therapy Phase I/II HIV SyStemix
HGP-30 vaccine Phase I HIV Viral Technologics
HIV immune globulin (HIVIG) immunomodulator Phase III Prevention of maternal/fetal HIV transfer North American Biologicals
HIV immuno-therapeutic antiviral Phase I HIV (symptomatic) Viagene
HIV immuno-therapeutic vaccine antiviral Phase II/III HIV asymptomatic Immunization Products Ltd. (joint venture of RPR and Immune Response Corp.)
HIV-IT (V) gene therapy Phase II IV Chiron
HIV Therapeutic other Phase I/II HIV/AIDS United Biomedical
HIV vaccine (gp120) antiviral Phase I AIDS Chiron/Ciba-Geigy
HIV Vaccine (Apollon) vaccine HIV Genevax
HIV Vaccine (Genevax) vaccine Phase I/II, HIV prophylaxis Apollon, Wyeth-Ayerst
HIV-1 peptide vaccine vaccine Phase I HIV National Cancer Institute
Hypericin (VIMRxyn
) antiviral Phase I AIDS, HIV VIMRx Pharm
Immune globulin IV 1 (IGIV; eg, Gamimune-N) immunomodulator Phase II/III Pediatric HIV; with zidovudine for AIDS Miles
Imreg-1
immunomodulator Phase III HIV Imreg
Interferon alfa (Wellferon) cytokine Phase III with zalcitabine and zidovudine for HIV disease, non-AIDS Glaxo Wellcome
Interferon, alfa-2b 1 (Intron A) cytokine Phase I/II with zidovudine for AIDS Schering-Plough
Interferon, alfa-n3 1 (Alferon N
; Alferon LDO
[low-dose oral]) cytokine Phase I/II ARC, AIDS, asymptomatic AIDS Interferon Sciences
Interferon, beta (Betaseron) cytokine Phase II/III AIDS Berlex
Interleukin-1receptor, soluble antiviral Phase I HIV Immunex
Interleukin-2 PEG cytokine Phase II with zidovudine for AIDS Chiron
Interleukin-3, recombinant human cytokine Phase I HIV with cytopenia Sandoz
Iscador antiviral Phase I HIV, AIDS Hiscia
Lentinan (Lentinan-
jinomoto) immunomodulator Phase II/III with didanosine for AIDS HIV-positive (symptomatic/asymptomatic), AIDS, pediatric AIDS Lenti-Chemico Pharmaceuticals
MDX-240 Phase II AIDS Medarex
Molgramostim (GM-CSF; (Leucomax) cytokine Phase II/III With zidovudine for AIDS Sandoz/Genetics Institute/Schering-Plough
Monoclonal antibody (MSL-109; MAb) antiviral Phase I AIDS Sandoz
Nelfinavir (Viracept) antiviral Phase III Agouron
Novapren
antiviral Phase I HIV inhibitor Novaferon Labs
Panavir (probucol) antiviral Phase II HIV, AIDS Vyrex
Panretin Oral (ALRT 1057) immunomodulator Phase I/II HIV Ligand Pharma Allergan-Ligand
Pentafuside Phase I/II HIV MiniMed
PMEA (GS 393) antiviral Phase I/II HIV Gilead Sciences
PMPA other Phase I/II HIV Gilead Sciences
PNU-140690 (protease inhibitor) antiviral Phase I HIV, AIDS Pharmacia & Upjohn
Proleukin aldesleukin, interleukin-2 (IL-2) immunomodulator Phase II HIV Chiron
RBC-CD4 antiviral Phase I/II HIV Sheffield Medical Tech.
Remune HIV immunotherapeutic vaccine Phase III IV Immune Response
rhIL-12 (recombinant human interleukin-12) immunomodulator Phase I HIV Genetics Institute
Ribavirin 1 (Virazole) antiviral Phase II/III Asymptomatic HIV posi- tive; IND denied Viratek/ICN
Roquinimex (Linomide) immunomodulator Phase II HIV Kabi Pharmacia
Sargramostim 1 (granulocyte macrophage colony stimulating factor; GM- CSF; Leukine) cytokine Phase II HIV Immunex
SPC3 other Phase I/II HIV Columbia Laboratories
Stimulon QS-21 vaccine Phase I/II Aquila Biopharmaceuticals
T4, soluble human, recombinant antiviral Phase I/II HIV Biogen
TAT antagonist antiviral Phase I/II IV Hoffman LaRoche
TBC-3B vaccine Phase I AIDS Therion Biologics
T-cell gene therapy gene therapy Phase III HIV Cell Genesys
Thalidomide cytokine inhibitor Approvable AIDS Celegene
Thymic humoral factor immunomodulator Phase I HIV Adria
Thymopentin (Timunox) immunomodulator Phase III Asymptomatic HIV Immunobiology Research Institute
Thymostimuline (TP-1) immunomodulator Phase III AIDS Serono Laboratories
Timunox thymopentin immunomodulator Phase III HIV Immunobiology Research Institute
Tirilazed Mesylate protease inhhibitor Phase I/II HIV Glaxo Wellcome
Trichosanthin (GLQ223
; Compound Q) antiviral Phase II ARC, AIDS Genelabs Technologies
Tucaresol (immunopotentiator) antiviral Phase I/II HIV Glaxo Wellcome
Tumor necrosis factor (TNF) antiviral Phase I HIV Immunex
Veldona
cytokine Phase I AIDS Veldona USA
Videx (didanosine with Retrovir
zidovidine [AZT]) antiviral application submitted HIV Bristol-Myers Squibb
Videx (didanosine [ddI] with Zerit
stavudine [d4T]) antiviral application submitted HIV Bristol-Myers Squibb
VIMRxyn hypericin antiviral Phase I HIV, AIDS VIMRx Pharma
VX478 antiviral Phase II AIDS, HIV Vertex Pharmaceuticals
Zintevir (AR177) antiviral Phase I/II HIV Aronex Pharmaceuticals
1 Approved for other indications; refer to individual monographs.
RECENT APPROVALS
Provigil (Cephalon) - Rx
Tablets: 100 mg modafinil. (Provigil 100 mg). In 100s.
200 mg modafinil. (Provigil 200 mg). Scored. In 100s. White. Lactose, talc.
Indications: Improve wakefulness with excessive daytime sleepiness in narcoleptic patients.
LYMErix Vaccine (SmithKline Beecham) - Rx
Injection: 30 mcg/0.5 ml recombinant lipoprotein OspA adsorbed onto 0.5 mg aluminum hydroxide adjuvant. In single-dose vials and prefilled syringes.
Indications: Active immunization against Lyme disease in patients 15 to 70 years of age.