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Indications for Prenatal Diagnostic Testing for Birth Defects
Cytogenetic Indications
Single gene disorder in a sibling or carrier parent
Multifactorial disorder in first-degree relatives
Routine Assessment of Intrauterine Growth and Maturation
Document maturity and EDC
Assessment of Continued Growth
Assessment of Pulmonary Maturity
Assessment of Placental Integrity
Periumbilical Blood Sampling (PUBS)
Intrapartum Assessment
Testing During pregnancy | |
Time (week) | Assessment |
Initial (as early as possible) |
Hemoglobin or hematocrit measurement
Urinalysis, including microscopic examination and infection screen Blood group and Rh type determinations Antibody screen Rubella antibody titer measurement Syphilis screen Cervical cytology Hepatitis B virus screen |
8-18 |
Ultrasound
Amniocentesis Chorionic villus sampling Maternal serum alpha-fetoprotein |
26-28 |
Diabetes screening
Repeat hemoglobin or hematocrit measurement |
28 |
Repeat antibody test for unsensitized Rh-negative patients
Prophylactic administration of Rho(D) immune globulin |
32-36 |
Ultrasound
Testing for sexually transmitted disease Repeat hemoglobin or hematocrit measurement Culture for Group B streptococcal colonization |