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Exclude, eliminate or kill foreign invasion
Develop memory and amplified recall response
Deficits result in
Increased frequency or severity of infections with pathogens
Infections with nonpathogenic, opportunistic organisms
Barriers - skin and mucus membranes, normal flora, spleen
Opsonins - complement, collectins, CRP
Phagocytes - neutrophils, monocytes, macrophages and NK cells
Host Defense Immunodeficiency
CD4 T cells (helper/master control)
Cytokines -IL-2, IFN-d TNF-a/IL-4, IL-5
Cognate help for APC/B cells via CD40 ligand
CD8 and 75 T Cells
Without GI Infections
Suspect deficit in innate, respiratory mucosal defenses, allergy or humoral immunity
With GI Infections
Suspect host defense, immunodeficiency antibody deficiency