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Policystic Ovary Syndrome and Hirsutism

Stein and Leventhal: first report of seven amenorrheic women with smooth, enlarged ovaries, who ovulated following wedge polycistic ovary syndrome

The advent of radioimmunoassay

Clinical Features

Obesity: seen in at least 50% of women with polycistic ovary syndrome (PCO).

Upper body obesity is frequently characteristic

Oligomenorrhea or amenorrhea

Hirsutism 1. Not always present 2. Hirsutism is a function of both target tissue response and hyperandrogenism

Premenarchal onset of symptoms



Biochemical Features

Increased free testosterone: if not present, the diagnosis is suspect; the most reliable biochemical indicator of the disorder

Decreased sex hormone-binding globulin polycystic ovary syndrome, hirsutism (SHBG): a consequence of both elevated androgen secretion and obesity

Increased luteinizing hormone (LH): not always present, and may vary from time to time polycystic ovary syndrome

D. Normal follicle-stimulating hormone (FSH)

E. Prolactin occasionally elevated

F. Dehydroepiandrosterone sulfate often elevated: no longer viewed as evidence of intrinsic adrenal dysfunction

G. Insulin resistance

G. Insulin resistance