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Cystosarcoma phylloides

Cystosarcoma phylloides, an uncommon breast tumor in adults, may occur in adolescents. It is characterized by asymmetric breast enlargement in association with a firm, mobile, circumscribed mass. Often the tumor increases rapidly in size and can become quite large. Fixation of the tumor to the skin or

The majority of these tumors are benign, but malignant cystosarcoma phylloides with metastases has been reported. Excision is the preferred initial therapy in the adolescent patient, regardless of the histologic classification of the lesion. Malignant cystosarcoma is more likely to recur than is a benign lesion. Fatal metastatic cystosarcoma phylloides in an adolescent.

Breast tumors also may be the first manifestation of relapse (extramedullary) in acute lymphoblastic leukemia. Reports in the literature include a case of radiation-induced sarcoma of the breast in a female adolescent and a case of liposarcoma in a 17-yr-old black female who previously had a total mastectomy.