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Gastroenteritis
Acute gastroenteritis is defined as diarrheal disease of rapid onset, often with nausea, vomiting, fever, or abdominal pain. It occurs an average of 1.3-2.3 times per year between the ages of 0 and 5 years diarrhea, salmonella, rotavirus, shigella, gastroenteritis, ecoli, e coli. Rates among children in child care centers are
Viral Gastroenteritis
All of the viruses produce watery diarrhea often accompanied by vomiting and fever, usually not associated with blood or leukocytes in the stool or with
Rotavirus is the predominant viral cause of dehydrating diarrhea. Rotaviral infections tend to produce severe diarrhea, causing up to 70% of episodes in children under 2 years of age who require hospitalization. Rotavirus infection tends to occur in the fall in the southwest of the US, then sweeping progressively
Norwalk viruses are the major cause of large epidemics of acute nonbacterial gastroenteritis. In schools, camps, nursing homes, cruise ships, and restaurants.
Enteric adenovirus is the third most common organism isolated in infantile diarrhea.
Bacterial Gastroenteritis
The bacterial diarrheas work through the elaboration of toxin (enterotoxigenic pathogens) or through invasion and inflammation of the
Secretory diarrheas are modulated through an enterotoxin, and the patient does not have systemic symptoms (fever, myalgias) or signs of local irritation of the bowel (tenesmus), or evidence of gut inflammation in the stool (white or red blood cells). The diarrhea is watery, often is large in volume, and often associated with nausea and
Invasive diarrhea is caused by bacterial enteropathogens, and is accompanied by systemic signs, such as fever, myalgias, arthralgias, irritability, and loss of appetite. Cramps and abdominal pain are prominent. The diarrhea consists of the frequent passing of small amounts of "mucousy" stool. Stool examination reveals leukocytes, red blood cells, and often
The same organisms that typically cause an invasive or inflammatory pattern of illness also may cause a secretory or
Acute Diarrhea Patterns and Associated Pathogens
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Secretory/enterotoxigenic
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Inflammatory
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Characterized by watery diarrhea and absence of fecal leukocytes
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Characterized by dysentery (ie, symptoms and bloody stools), fecal leukocytes, and erythrocytes
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Food poisoning (toxigenic)
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Staphylococcus aureus
Bacillus cereus
Clostridium perfringens
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Shigella
Invasive E coli
Salmonella
Campylobacter
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Enterotoxigenic
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Escherichia coli
Vibrio cholera
Giardia lamblia
Cryptosporidium
Rotavirus
Norwalk-like virus
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C difficile
Entameba histolytica
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Clinical Evaluation and Treatment of Acute Diarrhea
Step One--Assess child for degree of dehydration
No dehydration
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Continue oral hydration and feeding
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Some/severe dehydration--------->
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Initiate rehydration by oral route (intravenous for severely dehydrated patients)
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Step Two--Assess Clinical History for Etiologic Clues
Etiologic Clue
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Etiology Suggested
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Fever, crampy abdominal pain, tenesmus
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Inflammatory colitis or ileitis
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History of bloody stool
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Shigella, enteroinvasive EC, amebiasis, other bacterial causes
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Fever and abdominal pain and like appendicitis
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Yersinia enterocolitis
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Current or previous antibiotic use
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Antibiotic-associated enteritis or pseudomembranous colitis
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Multiple cases and common food source
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Incubation <6 hours: Staphylococcus aureus, Bacillus cereus
Incubation >6 hours: Clostridium perfringens
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Ingestion of inadequately cooked seafood
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Vibrio sp
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Recent measles, severe malnutrition, AIDS, other causes of immunosuppression
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Bacterial (Salmonella), viral (rotavirus), or parasitic (isosporiasis, Cryptosporidium)
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Step Three--Examine Stool:
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Indicated for:
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Finding:
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Etiology Suggested:
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Visual examination of specimen
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All patients
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Gross blood
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Dysentery, colitis, invasive organism
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Microscopic
examination for
white/red blood cells
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Patients who have had diarrhea >3 days, fever, blood in stool, weight loss beyond fluid deficit
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Red cells and leukocytes
Red cells without leukocytes
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Shigella, enterohemorrhagic EC, enteroinvasive EC, Campylobacter, Clostridium, E histolytica
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Parasitic examination (wet mount, acid-fast staining, or concentration)
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Diarrhea >10 days
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Positive
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Giardia, Amoeba, Cryptosporidium, Isospora, Strongyloides
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Clostridium difficile toxin
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Especially patients taking antibiotics
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Positive
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C difficile colitis
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Fluid Therapy
Mild-to-moderate dehydration
Oral rehydration therapy (ORT) is the preferred method. ORT is a glucose-electrolyte solution.
Mildly or moderately dehydrated children should receive ORT at 50 mL/kg (mild dehydration) or 100 mL/kg (moderate dehydration) over a 4-hour period. Replacement of stool losses (at 10 mL/kg for each stool) and of emesis (estimated volume) will require adding appropriate amounts of solution to the total.
If all but sips of fluid are vomited, oral hydration can be achieved by administering a
Clinical Evaluation and Treatment of Persistent Diarrhea-lasting longer than 14 Days
Step--One
Assess child for degree of dehydration ------------> Appropriate rehydration
Step–Two. Assess Etiologic Clues
Etiologic Clue
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Etiology Suggested
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Bloody stool
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Invasive organism, particularly Shigella and Entameba histolytica
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Malnutrition (inadequate weight for age)
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Inadequate diet, decreased resistance
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Dietary changes, especially addition of milk or formula
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Possible milk or protein hypersensitivity
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Problems following milk ingestion
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Lactose malabsorption
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Antibiotic treatment
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Antibiotic-associated enterocolitis or resistant organism
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Step–Three. Stool Examination
Test
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Finding
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Etiology Suggested
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Visual examination
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Bloody stool
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Invasive organism
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Microscopic stool exam, including search for ova, parasites, and Cryptosporidium
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Red and white blood cells
E histolytica cysts
Giardia, E histolytica trophozoites
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Shigella, other invasive organism
Etiologic role unclear
Etiologic role more likely; specific treatment indicated
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Stool pH, reducing substances
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pH <5.5 and ++ reducing substances
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Lactose or other carbohydrate malabsorption.
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Stool culture and sensitivity
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Pathogens present
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Etiology and antibiotic treatment
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