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Urinary Incontinence

Incontinence and urinary tract complaints are common among women. Approximately 10-30% of women between 15 and 64 years of age and 25% more than 65 years of age experience urinary incontinence. About 50% of nursing home residents have urinary incontinence overactive bladder, stool leakage, soiling, incontenence. One in five women with urinary incontinence also suffer from anal incontinence. Many of these symptoms may be relieved by interventions; therefore, patients benefit greatly when their physician understands prevention, pathophysiology, evaluation, and treatment of these common disorders. The obstetrician-gynecologist plays a pivotal role in the initial evaluation and treatment of women with these

Urinary Incontinence

The two most common forms of urinary incontinence in ambulatory women are genuine stress incontinence and detrusor overactivity. Most women with genuine stress incontinence (loss of urine associated with physical exertion such as coughing, sneezing, running, lifting, and jumping) have loss of support of the urethral sphincter. Vaginal delivery alters the support in the vagina, especially the anterior wall. The use or avoidance of episiotomy does not appear to influence the incidence of stress incontinence. This form of "hypermobility" incontinence responds well to correction of the displacement with either vaginal support devices or repositioning surgery. Genuine stress incontinence also may occur in nulliparous women who have some

Glossary

Cystometrography.'a measure of bladder pressure as the bladder is filled with a known volume of fluid

Cystourethrocele: a condition in which the bladder neck

has lost anatomic support

Detrusor hyperreflexia (also called detrusor sphincter dyssynergia): a recognized neurologic process that causes detrusor overactivity

Detrusor instability (also ca/led urge incontinence or unstable bladder).' idiopathic overactivity of the bladder smooth muscle; the occurrence of involuntary uninhibited detrusor contractions, which generally cause symptoms of urgency, frequency, nocturia, and incontinence

Detrusor overactivity: overactivity of the bladder smooth muscle, caused by idiopathic or neurologic disorder

Functional incontinence: involuntary urine loss resulting from physical disabilities such as severe arthritis, rendering the patient unable to reach the bathroom in time or causing difficulty in removing clothing, or psychologic or psychiatric disorders

Genuine stress incontinence: involuntary loss of urine occurring when, in the absence of detrusor contraction, the intravesical pressure exceeds the maximal urethral pressure

Overflow incontinence: involuntary loss of urine associated with overdistension of the bladder; symptoms include frequency as well as incontinence

Potential incontinence: genuine stress incontinence that is unmasked as a result of surgery for pelvic organ prolapse or that occurs temporarily when a severe prolapse is mechanically reduced with a pessary or other device

PVR volume: postvoid residual volume

Stress incontinence: loss of urine associated with physical exertion such as coughing, sneezing, running, lifting, and jumping

Urinary incontinence: involuntary loss of urine sufficient to be a problem to the patient

Detection of Urinary Incontinence

Every obstetrician-gynecologist has patients with urinary incontinence. Physicians can detect this condition by inquiring about it regularly. Of women who have had a recent vaginal delivery, one fifth will develop incontinence; among this group, early

It is estimated that one third of women with urinary incontinence have both detrusor overactivity and genuine stress incontinence. The physician's role is to focus on the symptoms that are most bothersome and reduce the impact of these symptoms for the

Initial Evaluation

Once urinary incontinence is reported, office evaluation should follow a stepwise progression. Initial evaluation should focus on the severity of urinary leakage and the patient's goals for resolution of the problem. Some women may simply wish to regain sufficient bladder control to participate in certain social or athletic activities. Their goal may not necessarily be complete

Identification and Management of Reversible Conditions That Cause or Contribute to Urinary Incontinence

Condition

Management

Conditions Affecting the Lower Urinary Tract

Urinary tract infection

(symptomatic with frequency, urgency, dysuria, etc)

Atrophic vaginitis/urethritis

Pregnancy/vaginal delivery/episiotomy

Stool impaction

Drug Side Effects*

Diuretics

Polyuria, frequency, and urgency

Caffeine

Aggravation or precipitation of urinary incontinence

Anticholinergic agents

Urinary retention, overflow incontinence, impaction

 

Psychotropic agents

Antidepressants: anticholinergic actions, sedation

Antipsychotics: anticholinergic actions, sedation,

rigidity, and immobility

Sedatives/hypnotics/central nervous system

depressants: sedation, delirium, immobility,

muscle relaxation

Narcotic analgesics

Urinary retention, fecal impaction, sedation, delirium

"-Adrenergic blockers

Urethral relaxation

"-Adrenergic agonists

Urinary retention (present in many cold and diet over-the-counter preparations)

$-Adrenergic agonists

Urinary retention

Calcium channel blockers

Urinary retention

Alcohol

Polyuria, frequency, urgency, sedation, delirium,

immobility

Increased Urine Production

Metabolic (hyperglycemia, hypercalcemia)

 

Excess fluid intake

Volume overload

 

Increased Urine Production

Venous insufficiency with edema

Congestive heart failure

Impaired Ability or Willingness to Reach a Toilet Delirium

 

Chronic illness, injury, or restraint that interferes with mobility

Psychologic

 

 

Antimicrobial therapy

Oral or topical estrogen

Behavioral intervention; avoid surgical therapy postpartum as condition may be self-limiting

Disimpaction; appropriate use of stool softeners, bulk-forming agents, and laxatives if necessary; implement high-fiber intake, adequate mobility, and fluid intake

With all medications, discontinue or change therapy, as clinically possible; dosage reduction or modification (eg, flexible scheduling of rapid-acting diuretics) also may help

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Better control of diabetes mellitus; therapy for hypercalcemia

depends on underlying cause

Reduction in intake of diuretic fluids (eg, caffeinated beverages)

 

 

 

 

Support stocking, leg elevation, sodium restriction, diuretic therapy

Medical therapy

 

Diagnosis and treatment of underlying cause(s) of acute confusional state

Regular toileting, use of toilet substitutes, environmental alterations (eg, bedside commode, urinal)

Remove restraints if possible; appropriate pharmacologic or

nonpharmacologic treatment or both

 

Initial Interventions

Behavioral Therapies

Behavioral therapies are helpful to virtually every patient with urinary incontinence. Many patients have adopted behavioral changes in their own attempts to control incontinence symptoms. The physician can save time and have a more direct impact by inquiring what the patient has already tried on her own.

Simple techniques may be discussed, including adjustment of type and volume of fluid intake after review of the urinary diary. Older patients frequently have nocturnal diuresis. The diaries of these patients reflect several episodes of nighttime voiding,

Muscle Training

Women with weakened pelvic floor muscles may benefit from muscle-training protocols. These are helpful for patients with detrusor overactivity or stress incontinence. There are two important components to muscle rehabilitation: 1) strength and 2) appropriate timing of contraction of these muscles.

The physician's role is critical in identifying muscle weakness and emphasizing the importance of muscle rehabilitation. Strength can be gained through a variety of exercise programs. There is little scientific evidence to suggest any specific muscle-training

Kegel Exercises

Pelvic muscle exercises (Kegel exercises) help improve urinary control in 40-75% of patients. The patient performs the exercise by contracting the pubococcygeus muscle, thus improving the tone of the voluntary external urethral musculature. Exercises are indicated in patients with either stress or urge incontinence. The success of pelvic muscle exercises depends on the

Electrical Stimulation

Electrical stimulation with a transvaginal probe reduces detrusor overactivity in approximately 50% of affected women. Like timed voiding and muscle training, this treatment is free of systemic side effects. The main drawback is the cost of rental or

Vaginal and Urethral Devices

An increasing selection of vaginal and urethral devices are available in North America. This appears to be the fastest-growing type of incontinence therapy. Pessaries that are modified for incontinence (Fig. 14) provide additional suburethral pressure and are safe and reasonably effective. A bladder support prosthesis is significantly more expensive and more cumbersome to fit than

Intrinsic urethral sphincter dysfunction has been treated by periurethral bulking injections to improve urethral coaptation. Injections have been used in women with a well-supported but poorly functioning intrinsic urethra; short-term cure rates approach 70-90%. Periurethral collagen injections are not indicated in women with urethral hypermobility because 

Pharmacotherapy

There is no ideal medication for the treatment of incontinence. In general, drug treatment is used for detrusor overactivity and is aimed at reducing inappropriate detru-sor contractions. Less commonly, (z-receptor stimulants are used to increase urethral tone in an effort to reduce stress incontinence episodes. These medications stimulate ct receptors throughout the body (eg, cardiovascular system) and may cause hypertension.

Drugs for detrusor overactivity are typically anticholinergic agents. Thus, the side effect profile includes dry mouth and worsening constipation. Narrow-angle glaucoma is an absolute contraindication to use of this class of medications; they should be used cautiously in women with significant cardiovascular disease. Oxybutynin chloride and tolterodine are the only medications in this class with scientific evidence for efficacy for detrusor overactivity. Oxybutynin chloride is available in generic formulations and, therefore, has the advantage of reduced cost. Tolterodine may have fewer side effects and is a reasonable second-line

Women with mixed urinary incontinence may benefit from imipramine hydrochloride. This medication offers a combination of anticholinergic medication for detrusor suppression and (z-receptor sympathomimetic activity to

Fecal Incontinence

The estimates of the prevalence of fecal incontinence in the adult female population range between 1% and 17%. This disorder, defined as involuntary passage of gas, liquid, or solid stool, is even more stigmatized than urinary incontinence. Approximately one in five women with urinary incontinence also have some form of anal incontinence. For most women seeking care for

Therapy

Therapeutic considerations depend on the diagnosis discovered by the evaluation. If no surgical defect is demonstrated, the goal of therapy is to help the patient maintain a state of formed stool and to make every effort to keep the rectum empty. Recommendations will include dietary modifications (mostly to increase fiber) and muscle exercises, much as are