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Meprozine (Meperidine/Promethazine)

Indications: Anesthesia, adjunct; Pain, moderate

DRUG CLASS: Analgesics, Narcotic

BRAND NAMES: Mepergan; Meprozine 

INDICATIONS AND USAGE:
Capsules

Affords sedation as well as analgesia for moderate pain as seen in postoperative patients, postpartum patients, and in patients with pain associated with malignancies.

As a preanesthetic medication when analgesia and sedation are indicated. As an adjunct to local.

DOSAGE

The usual dosage is one capsule every 4 to 6 hours as needed for the relief of pain.
Injection

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.

WARNING--BARBITURATES ARE NOT CHEMICALLY COMPATIBLE IN SOLUTION WITH MEPERIDINE HCl; PROMETHAZINE HCl AND SHOULD NOT BE 

The Tubex Sterile Cartridge-Needle Unit is designed for single-dose use. Vials should be used when required doses are fractions of a milliliter.

Meperidine HCl; Promethazine HCl is usually administered intramuscularly. However, in certain specific situations, the intravenous route.

 INADVERTENT INTRA-ARTERIAL INJECTION CAN RESULT IN GANGRENE OF THE AFFECTED EXTREMITY. SUBCUTANEOUS ADMINISTRATION IS CONTRAINDICATED, AS IT MAY RESULT IN TISSUE NECROSIS. INJECTION INTO OR NEAR PERIPHERAL NERVES MAY RESULT IN PERMANENT NEUROLOGICAL DEFICIT.

When used intravenously, the rate should not be greater than 1 ml meperidine HCl; promethazine HCl (25 mg of each component) per minute; it is preferable to inject through the tubing of an intravenous infusion.

Adult Dose: 1 to 2 ml (25 to 50 mg of each component) per single injection, which can be repeated.

Children 12 Years of Age and Under: 0.5 mg of each component per pound of body weight. The dosage may be repeated every 3 to 4 hours as necessary. For preanesthetic medication the usual adult dose is 2 ml (50 mg of each component) intramuscularly with or without appropriate atropine-like drug. Atropine sulfate, 0.3 to 0.4 mg, or scopolamine hydrobromide, 0.25 to 0.4 mg, in sterile solution may be mixed in the same syringe with meperidine HCl; promethazine HCl. Repeat doses of 50 mg or less of both promethazine and meperidine may be administered by either route at 3- to 4-hour intervals, as necessary. As an adjunct to local or general anesthesia, the usual dose is 2 ml (50 mg each of meperidine.